The synthesis and antileishmanial activity of 18 edelfosine analogs, e.g. I, are described. Compds. were obtained in parallel combining solid phase and soln. phase synthesis. The most active analog is characterized by the octadecyl group in position 2 of the glycerol chain. Considering that this substitution dets. the loss of antitumor activity, a different mechanism of antileishmanial action can be hypothesized

Parallel synthesis and antileishmanial activity of ether-linked phospholipids / P. Coghi, N. Vaiana, M.G. Pezzano, L. Rizzi, M. Kaiser, R. Brun, S. Romeo. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18:16(2008), pp. 4658-4660. [10.1016/j.bmcl.2008.07.022]

Parallel synthesis and antileishmanial activity of ether-linked phospholipids

P. Coghi
Primo
;
N. Vaiana
Secondo
;
M.G. Pezzano;L. Rizzi;S. Romeo
Ultimo
2008

Abstract

The synthesis and antileishmanial activity of 18 edelfosine analogs, e.g. I, are described. Compds. were obtained in parallel combining solid phase and soln. phase synthesis. The most active analog is characterized by the octadecyl group in position 2 of the glycerol chain. Considering that this substitution dets. the loss of antitumor activity, a different mechanism of antileishmanial action can be hypothesized
Antiprotozoal activity; Edelfosine; Ether-linked phospholipids; Leishmania donovani; Parallel synthesis
Settore CHIM/08 - Chimica Farmaceutica
2008
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/55261
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