Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors / F. Faggioli, S. Soldati, E. Scanziani, E.M. Catò, F. Adorni, P. Vezzoni, D.M. Noonan, M.G. Sacco. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 110:2(2008), pp. 223-226.
Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors
E. Scanziani;
2008
Abstract
Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
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