The clearance of apoptotic cells is a highly regulated mechanism, normally associated with antiinflammatory response. During early stages of apoptosis the cell is promptly recognized and engulfed by professional phagocytes or tissue cells to avoid the outflow of intracellular content and limit the immunological reaction against released antigens. However, increasing evidences suggest that impairment in the uptake of apoptotic cell debris is linked to the development of autoimmunity. In fact, autoantigens have been demonstrated to be content within apoptotic bodies and apoptotic cells seems to be critical in the presentation of antigens, activation of innate immunity and regulation of macrophage cytokine secretion. We herein review the known mechanisms for regulating the uptake of the products of apoptosis in the development of autoimmunity.

The consequences of apoptosis in autoimmunity / A. Lleo, C. Selmi, P. Invernizzi, M. Podda, ME. Gershwin. - In: JOURNAL OF AUTOIMMUNITY. - ISSN 0896-8411. - 31:3(2008 Nov), pp. 257-262. [10.1016/j.jaut.2008.04.009]

The consequences of apoptosis in autoimmunity

A. Lleo;C. Selmi;P. Invernizzi;M. Podda;
2008

Abstract

The clearance of apoptotic cells is a highly regulated mechanism, normally associated with antiinflammatory response. During early stages of apoptosis the cell is promptly recognized and engulfed by professional phagocytes or tissue cells to avoid the outflow of intracellular content and limit the immunological reaction against released antigens. However, increasing evidences suggest that impairment in the uptake of apoptotic cell debris is linked to the development of autoimmunity. In fact, autoantigens have been demonstrated to be content within apoptotic bodies and apoptotic cells seems to be critical in the presentation of antigens, activation of innate immunity and regulation of macrophage cytokine secretion. We herein review the known mechanisms for regulating the uptake of the products of apoptosis in the development of autoimmunity.
Autoantibodies; Cell clearance; Lupus
Settore MED/09 - Medicina Interna
nov-2008
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/53147
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