We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-alpha (IFN-alpha) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-alpha as immunomodulating drug
Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-alpha treatment in a suspected case of hyper-IgE syndrome / U. Benninghoff, F. Cattaneo, A. Aiuti, A. Flores-D'Arcais, C. Gelmetti, M. Viscardi, L. Callegaro, M. Mirolo, A. Ambrosi, M.G. Roncarolo, R. Bacchetta. - In: PEDIATRIC ALLERGY AND IMMUNOLOGY. - ISSN 0905-6157. - 19:6(2008), pp. 564-568.
Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-alpha treatment in a suspected case of hyper-IgE syndrome
C. Gelmetti;
2008
Abstract
We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-alpha (IFN-alpha) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-alpha as immunomodulating drug
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