AIM: To analyze the association of p53 overexpression in index colorectal adenomas with metachronous adenomas development. METHODS: A total of 46 patients who underwent endoscopic polypectomy were followed by complete colonoscopy every six months for four years to remove any metachronous adenomas. All adenomas removed were immunostained with a monoclonal antibody against the p53 protein on formalin-fixed, paraffin-embedded materials. RESULTS: Among the 46 patients studied, 16 developed metachronous adenomas (group I), while 30 were free of recurrence (group II). The overexpression of p53 was significantly higher in group I than in group II. CONCLUSIONS: Immunodetection of p53 overexpression might help to identify the group of patients where the risk of recurrence is the highest.
Association of p53 overexpression in index adenomas with metachronous adenomas development / G. Ottaviani, A.M. Lavezzi, L. Matturri. - In: CANCER DETECTION AND PREVENTION. - ISSN 0361-090X. - 1998:22(1998 Oct), pp. 99-99. ((Intervento presentato al 4. convegno International Symposium of International Society for Preventive Oncology (ISPO). “Impact of cancer biotechnology on diagnostic and prognostic indicators in predictive oncology and therapy” October 24-27th, 1998. tenutosi a Nice, France. nel 1998.
Association of p53 overexpression in index adenomas with metachronous adenomas development
G. OttavianiPrimo
;A.M. LavezziSecondo
;L. MatturriUltimo
1998
Abstract
AIM: To analyze the association of p53 overexpression in index colorectal adenomas with metachronous adenomas development. METHODS: A total of 46 patients who underwent endoscopic polypectomy were followed by complete colonoscopy every six months for four years to remove any metachronous adenomas. All adenomas removed were immunostained with a monoclonal antibody against the p53 protein on formalin-fixed, paraffin-embedded materials. RESULTS: Among the 46 patients studied, 16 developed metachronous adenomas (group I), while 30 were free of recurrence (group II). The overexpression of p53 was significantly higher in group I than in group II. CONCLUSIONS: Immunodetection of p53 overexpression might help to identify the group of patients where the risk of recurrence is the highest.Pubblicazioni consigliate
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