Huntington disease (HD) is an inherited neurodegenerative disorder with unclear pathophysiology. We developed a high-throughput assay in a neuronal cell culture model of HD, screened 43,685 compounds and identified 29 novel selective inhibitors of cell death in mutant huntingtin-expressing cells. Four compounds were active in diverse HD models, which suggests a role for cell death in HD; these compounds are mechanistic probes and potential drug leads for HD
Selective inhibitors of death in mutant huntingtin cells / H. Varma, C. Voisine, C.T. DeMarco, E. Cattaneo, D.C. Lo, A.C. Hart, B.R. Stockwell. - In: NATURE CHEMICAL BIOLOGY. - ISSN 1552-4450. - 3:2(2007 Feb), pp. 99-100.
Selective inhibitors of death in mutant huntingtin cells
E. Cattaneo;
2007
Abstract
Huntington disease (HD) is an inherited neurodegenerative disorder with unclear pathophysiology. We developed a high-throughput assay in a neuronal cell culture model of HD, screened 43,685 compounds and identified 29 novel selective inhibitors of cell death in mutant huntingtin-expressing cells. Four compounds were active in diverse HD models, which suggests a role for cell death in HD; these compounds are mechanistic probes and potential drug leads for HD
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