The presence of an increased activity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with type 2 diabetes is debated. We evaluated cortisol secretion in 170 type 2 diabetic patients and in 71 sex-age-BMI-matched non-diabetic subjects.Logistic regression analysis showed that the presence of diabetes chronic complications was significantly associated with serum cortisol levels at midnight (F24), gender, duration of diabetes, and glycated hemoglobin. In conclusion in type 2 diabetic patients HPA axis activity is enhanced in patients with diabetic complications and the degree of cortisol secretion is related to the presence and number of diabetes complications.
Cortisol secretion in patients with type 2 diabetes : relationship with chronic complications / I. Chiodini, G. Adda, A. Scillitani, F.M. Coletti, V. Morelli, S. Di Lembo, P. Epaminonda, B. Masserini, P.L.M. Beck-Peccoz, E. Orsi, B.E. Ambrosi, M. Arosio. - In: DIABETES CARE. - ISSN 0149-5992. - 30:1(2007), pp. 83-88.
Cortisol secretion in patients with type 2 diabetes : relationship with chronic complications
I. Chiodini;F.M. Coletti;V. Morelli;S. Di Lembo;B. Masserini;P.L.M. Beck-Peccoz;E. Orsi;B.E. AmbrosiPenultimo
;M. ArosioUltimo
2007
Abstract
The presence of an increased activity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with type 2 diabetes is debated. We evaluated cortisol secretion in 170 type 2 diabetic patients and in 71 sex-age-BMI-matched non-diabetic subjects.Logistic regression analysis showed that the presence of diabetes chronic complications was significantly associated with serum cortisol levels at midnight (F24), gender, duration of diabetes, and glycated hemoglobin. In conclusion in type 2 diabetic patients HPA axis activity is enhanced in patients with diabetic complications and the degree of cortisol secretion is related to the presence and number of diabetes complications.
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