Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3 complex and formins are the best studied. Arp2/3-complex activity is controlled through signalling-dependent association with nucleation-promoting factors, such as the WASP/WAVE family proteins. A common theme for these molecules, which is well established for WAVEs but is only just beginning to emerge for WASPs, is that they act as coincident detectors of a variety of signalling pathways through the formation of large multi-molecular complexes.

Protein complexes regulating Arp2/3-mediated actin assembly / T. E. B. Stradal, G. Scita. - In: CURRENT OPINION IN CELL BIOLOGY. - ISSN 0955-0674. - 18:1(2006 Feb), pp. 4-10.

Protein complexes regulating Arp2/3-mediated actin assembly

G. Scita
Ultimo
2006

Abstract

Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3 complex and formins are the best studied. Arp2/3-complex activity is controlled through signalling-dependent association with nucleation-promoting factors, such as the WASP/WAVE family proteins. A common theme for these molecules, which is well established for WAVEs but is only just beginning to emerge for WASPs, is that they act as coincident detectors of a variety of signalling pathways through the formation of large multi-molecular complexes.
Aldrich-syndrome protein; Clathrin-coated pits; wave family proteins; N-WASP; ARP2/3 complex; mediated endocytosis; filopodium formation; scar activity; T-cell; activation
Settore MED/04 - Patologia Generale
feb-2006
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/199387
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