A short synthetic strategy for the preparation of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gat-PYD), of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their respective epimers, Glc-Gal-epiPYD and Glc-Gal-epiHyl, useful for the analytical evaluation of collagen biomarkers in human sinovium and bone, is reported.

A simple strategy for the synthesis of the glycosylated collagen biomarkers alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gal-PYD), alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their unnatural epimers Glc-Gal-epiPYD and Glc-Gal-epiHyl / P. Allevi, E.A. Femia, E. Giannini, M. Anastasia. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 18:22(2007 Nov 12), pp. 2689-2694. [10.1016/j.tetasy.2007.10.037]

A simple strategy for the synthesis of the glycosylated collagen biomarkers alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gal-PYD), alfa-D-glucopyranosyl-(1->2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their unnatural epimers Glc-Gal-epiPYD and Glc-Gal-epiHyl

P. Allevi
Primo
;
E.A. Femia
Secondo
;
E. Giannini
Penultimo
;
M. Anastasia
Ultimo
2007

Abstract

A short synthetic strategy for the preparation of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gat-PYD), of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their respective epimers, Glc-Gal-epiPYD and Glc-Gal-epiHyl, useful for the analytical evaluation of collagen biomarkers in human sinovium and bone, is reported.
Glucosyl-glactosyl-pyridinoline ; osteoarthritis ; hydroxylysine
Settore BIO/10 - Biochimica
12-nov-2007
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/35599
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact