Preventing high-order multiple pregnancies during controlled ovarian hyperstimulation and intrauterine insemination: 3 years’ experience using low-dose recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists.

Objective: To employ protocols of mild ovarian stimulation to prevent an excessively elevated rate of high-order multiple pregnancies. Design: Case series. Setting: University hospital. Patient(s): Six hundred and twenty one consecutive patients undergoing 1,259 controlled ovarian hyperstimulation and intrauterine insemination cycles. Intervention(s): Patients received 50 IU per day of recombinant follicle-stimulating hormone (FSH) starting the third day of the cycle, then a gonadotropin-releasing hormone (GnRH) antagonist on the day in which a follicle 13 mm was visualized. Cycles were canceled if three or more follicles 16 mm and/or five or more follicles 11 mm were detected. Main Outcome Measure(s): Rate of high-order multiple pregnancies. Result(s): The clinical pregnancy rate per initiated cycle was 9.2% (95% confidence interval, 7.5–11.1%). The incidence of twins and high-order multiple pregnancies was 9.5% (95% CI, 5.3–16.2%) and 0 (0.0 –3.2%), respectively. Conclusion(s): In controlled ovarian hyperstimulation and intrauterine insemination cycles, a protocol of 50 IU of recombinant FSH daily combined with the use of GnRH antagonists and a policy of strict cancellation based on echographic criteria are associated with a satisfactory pregnancy rate per initiated cycle and a low risk of high-order multiple pregnancies.