OBJECTIVE: To report the case of five month old female baby with a history of episodes of gastro-oesophageal reflux and pneumonia. Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death. METHODS: Morphometric analysis was carried out with an Image-Pro Plus Image analyser (Media Cybernetics) on both sides of the brain stem. RESULTS: Hypoplasia and neuronal immaturity of the hypoglossal nucleus were demonstrated, accompanied by hypoplasia of the arcuate nucleus. CONCLUSIONS: Much attention should be paid to the possible role of the hypoglossal nucleus in determining a lethal outcome in infancy through impairment of deglutition and subsequent recurrent episodes of pneumonia, and as a necropsy finding.
Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death / G. Ottaviani, L. Matturri, R. Mingrone, A.M. Lavezzi. - In: JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0021-9746. - 59:5(2006 May), pp. 497-500. [10.1136/jcp.2005.032037]
Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death
G. Ottaviani
Primo
Writing – Original Draft Preparation
;L. MatturriSecondo
Supervision
;R. MingronePenultimo
Formal Analysis
;A.M. LavezziUltimo
Investigation
2006
Abstract
OBJECTIVE: To report the case of five month old female baby with a history of episodes of gastro-oesophageal reflux and pneumonia. Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death. METHODS: Morphometric analysis was carried out with an Image-Pro Plus Image analyser (Media Cybernetics) on both sides of the brain stem. RESULTS: Hypoplasia and neuronal immaturity of the hypoglossal nucleus were demonstrated, accompanied by hypoplasia of the arcuate nucleus. CONCLUSIONS: Much attention should be paid to the possible role of the hypoglossal nucleus in determining a lethal outcome in infancy through impairment of deglutition and subsequent recurrent episodes of pneumonia, and as a necropsy finding.File | Dimensione | Formato | |
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