: N-Alkyl and N-aryl 5-substituted oxazolidinones 12-19 were prepared in good to excellent yields by reaction of N-alkyl and N-aryl 1,2-amino alcohols 3-10 with S,S-dimethyldithiocarbonate (11) in the presence of solid NaOH under SL-PTC conditions. The procedure is particularly suitable for scale-up the process involving the use of cheap and ecosafe reagents under mild reaction conditions.
S,S-Dimethyl Dithiocarbonate as a Valuable Starting Material for the Synthesis of 5-Substituted Oxazolidinones under Solid-Liquid Phase Transfer Catalysis (SL-PTC) Conditions / Dario Landini, Matteo Salsa, Gianni Carvoli, Ilir Pecnikaj. - In: LETTERS IN ORGANIC CHEMISTRY. - ISSN 1570-1786. - 3:11(2006 Nov), pp. 836-841.
S,S-Dimethyl Dithiocarbonate as a Valuable Starting Material for the Synthesis of 5-Substituted Oxazolidinones under Solid-Liquid Phase Transfer Catalysis (SL-PTC) Conditions
Dario Landini;Matteo Salsa;
2006
Abstract
: N-Alkyl and N-aryl 5-substituted oxazolidinones 12-19 were prepared in good to excellent yields by reaction of N-alkyl and N-aryl 1,2-amino alcohols 3-10 with S,S-dimethyldithiocarbonate (11) in the presence of solid NaOH under SL-PTC conditions. The procedure is particularly suitable for scale-up the process involving the use of cheap and ecosafe reagents under mild reaction conditions.
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