Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD 149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD 149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multi-centre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationship between these reference materials when all results were included (5% significance level).

Long-term stability of relationships between reference materials for thromboplastins / TP. Linsinger, AMHP. van den Besselaar, A. Tripodi. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - 96:2(2006), pp. 210-214. [10.1160/TH06-03-0152]

Long-term stability of relationships between reference materials for thromboplastins

A. Tripodi
Ultimo
2006

Abstract

Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD 149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD 149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multi-centre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationship between these reference materials when all results were included (5% significance level).
Calibration; Reference material; Stability; Thromboplastin
Settore MED/15 - Malattie del Sangue
2006
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/30049
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