Sphingolipids are major constituents of biological membrane and some of them behave as second messengers involved in the cell fate decision. Ceramide and sphingosine 1-phosphate (S1P) constitute a rheostat system in which ceramide promotes cell death and S1P increases cell survival. We have shown that both sphingolipids are able to trigger autophagy with opposing outcomes on cell survival. Here we discuss and speculate on the diverging functions of the autophagic pathways induced by ceramide and S1P, respectively.
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? / Gregory Lavieu, Francesca Scarlatti, Giusy Sala, Thierry Levade, Riccardo Ghidoni, Joel Botti, Patrice Codogno. - In: AUTOPHAGY. - ISSN 1554-8627. - 3:1(2007), pp. 45-47.
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?
Francesca Scarlatti;Giusy Sala;Riccardo Ghidoni;
2007
Abstract
Sphingolipids are major constituents of biological membrane and some of them behave as second messengers involved in the cell fate decision. Ceramide and sphingosine 1-phosphate (S1P) constitute a rheostat system in which ceramide promotes cell death and S1P increases cell survival. We have shown that both sphingolipids are able to trigger autophagy with opposing outcomes on cell survival. Here we discuss and speculate on the diverging functions of the autophagic pathways induced by ceramide and S1P, respectively.
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