We assessed the effect of botulinum toxin type A (BTX-A) on phonic tics in patients with Tourette's syndrome. A total of 30 patients received 2.5 IU BTX-A (BOTOX; Allergan) in both vocal cords. All patients were assessed after 15 days and then 4 times over a 12-month period. At each visit the following data were collected: phenomenology of tics, global impression of changes by physician and patient, number of BTX-A injection given, interval between injections, time to response, duration of response, presence of post-injection hypophonia and side effects, presence of premonitory sesnory tic component, and interference with social life and work school activities. Vocal tics improved after treatment in 93% patients, with 50% being tic-free. Mean response time was 5.8 days, and mean duration of response was 102 days. Quality of life improved, and premonitory experiences dropped from 53% to 20%. Hypophonia was the only side effect of note (80% of patietns). BTX-A is an effective and safe treatment for phonic tics associated with Tourette's syndrome.
Treatment of phonic tics in patients with Tourette's syndrome using botulinum toxin type A / M. Porta, G. Maggioni, F. Ottaviani, A. Schindler. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 24:6(2004 Feb), pp. 420-423.
Treatment of phonic tics in patients with Tourette's syndrome using botulinum toxin type A
F. OttavianiPenultimo
;A. SchindlerUltimo
2004
Abstract
We assessed the effect of botulinum toxin type A (BTX-A) on phonic tics in patients with Tourette's syndrome. A total of 30 patients received 2.5 IU BTX-A (BOTOX; Allergan) in both vocal cords. All patients were assessed after 15 days and then 4 times over a 12-month period. At each visit the following data were collected: phenomenology of tics, global impression of changes by physician and patient, number of BTX-A injection given, interval between injections, time to response, duration of response, presence of post-injection hypophonia and side effects, presence of premonitory sesnory tic component, and interference with social life and work school activities. Vocal tics improved after treatment in 93% patients, with 50% being tic-free. Mean response time was 5.8 days, and mean duration of response was 102 days. Quality of life improved, and premonitory experiences dropped from 53% to 20%. Hypophonia was the only side effect of note (80% of patietns). BTX-A is an effective and safe treatment for phonic tics associated with Tourette's syndrome.Pubblicazioni consigliate
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