A process for the resolution of (D,L)-carnitinamide (D,L-I) chloride in its enantiomers (D-I) and (L-I), characterized in that a supersaturated solution or suspension of (D,L-I) in a suitable solvent or mixture of solvents, optionally added with a surfactant, is used. A series of alternate preferential crystallizations is carried out after adding minimum amount of seeds of one of the two enantiomers, (D-I) or (L-I), that is to be precipitated, and subsequently restoring the supersaturation conditions by adding an appropriate amount of (D,L-I) racemate.

Processo di risoluzione di un sale della carnitinammide / M. Pallavicini, E. Valoti, C. Bolchi, L. Fumagalli, O. Piccolo.

Processo di risoluzione di un sale della carnitinammide

M. Pallavicini;E. Valoti;C. Bolchi;L. Fumagalli;
2007

Abstract

A process for the resolution of (D,L)-carnitinamide (D,L-I) chloride in its enantiomers (D-I) and (L-I), characterized in that a supersaturated solution or suspension of (D,L-I) in a suitable solvent or mixture of solvents, optionally added with a surfactant, is used. A series of alternate preferential crystallizations is carried out after adding minimum amount of seeds of one of the two enantiomers, (D-I) or (L-I), that is to be precipitated, and subsequently restoring the supersaturation conditions by adding an appropriate amount of (D,L-I) racemate.
Università Studi Milano (70%)
Oreste Piccolo (30%)
EP1852416
EP6425304.0
7-nov-2007
Settore CHIM/08 - Chimica Farmaceutica
http://v3.espacenet.com/publicationDetails/biblio?CC=EP&NR=1852416A1&KC=A1&FT=D&date=20071107&DB=EPODOC&locale=en_EP
Processo di risoluzione di un sale della carnitinammide / M. Pallavicini, E. Valoti, C. Bolchi, L. Fumagalli, O. Piccolo.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/26194
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