High d. lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the redn. of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection

Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection / S. Bellosta, M. Gomaraschi, M. Canavesi, G.B. Rossoni, M. Monetti, G. Franceschini, L. Calabresi. - In: FEBS LETTERS. - ISSN 0014-5793. - 580:25(2006), pp. 5974-5978.

Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection

S. Bellosta
Primo
;
M. Gomaraschi
Secondo
;
M. Canavesi;G.B. Rossoni;M. Monetti;G. Franceschini
Penultimo
;
L. Calabresi
Ultimo
2006

Abstract

High d. lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the redn. of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection
Gelatinase A; High density lipoproteins; Ischemia/reperfusion injury; Matrix metalloproteinases; Myocardial ischemia
Settore BIO/14 - Farmacologia
2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/26181
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