Continued investigation of cytotoxic extracts of the marine sponge Crella sp. has resulted in the discovery of crellastatins I-M (2-6). Their structures were determined by interpretation of their NMR spectroscopic and FABMS data. These new bis-steroid derivatives exhibited cytotoxic activity against NSCLC cell lines with IC50 values in the range of 1-8 μg/ml.
Isolation and structural elucidation of the crellastatins I-M: cytotoxic bis-steroid derivatives from the vanuatu marine sponge Crella sp / C. Giannini, A. Zampella, C. Debitus, J.-L. Menou, C. Roussakis, M.V. D'Auria. - In: TETRAHEDRON. - ISSN 0040-4020. - 55:48(1999), pp. 13749-13756.
Isolation and structural elucidation of the crellastatins I-M: cytotoxic bis-steroid derivatives from the vanuatu marine sponge Crella sp
C. Giannini;
1999
Abstract
Continued investigation of cytotoxic extracts of the marine sponge Crella sp. has resulted in the discovery of crellastatins I-M (2-6). Their structures were determined by interpretation of their NMR spectroscopic and FABMS data. These new bis-steroid derivatives exhibited cytotoxic activity against NSCLC cell lines with IC50 values in the range of 1-8 μg/ml.
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