In Macaca mulatta, the single rDNA array is flanked by a patchwork of sequences including subregions of human Yp11.2, 4q35.2, and 10p15.3. This composite DNA region is characterized by unique or low-copy sequences, resembling a potentially transcribed region. The anal. of Cercopithecus aethiops, Presbytis cristata, and Hylobates lar suggests that this complex sequence organization could be shared by Old World monkey and lesser ape species. After the lesser apes/great apes divergence, the unique or nonduplicated DNA region underwent amplification and spreading, preferentially marking the p arm of acrocentric chromosomes bearing the rDNA. The mol. anal. of human acrocentric chromosomes revealed some extent of remodeling of the rDNA boundary: near the human NOR, a large 4q35.2 duplication partially resembles that found in MMU; conversely, infrequently represented Yp11.2 sequences totally differed from those of the macaque, and 10p15.3 sequences were lacking. Thus, although evolutionary events modified the sequence organization of the MMU rDNA boundary, its overall sequence feature and the preferential location in vicinity to the NOR have been conserved.

The boundary of macaque rDNA is constituted by low-copy sequences conserved during evolution / B. Bodega, M.F. Cardone, M. Rocchi, R. Meneveri, A. Marozzi, E. Ginelli. - In: GENOMICS. - ISSN 0888-7543. - 88:5(2006 Nov), pp. 564-571. [10.1016/j.ygeno.2006.05.001]

The boundary of macaque rDNA is constituted by low-copy sequences conserved during evolution

B. Bodega
Primo
;
A. Marozzi
Penultimo
;
E. Ginelli
Ultimo
2006

Abstract

In Macaca mulatta, the single rDNA array is flanked by a patchwork of sequences including subregions of human Yp11.2, 4q35.2, and 10p15.3. This composite DNA region is characterized by unique or low-copy sequences, resembling a potentially transcribed region. The anal. of Cercopithecus aethiops, Presbytis cristata, and Hylobates lar suggests that this complex sequence organization could be shared by Old World monkey and lesser ape species. After the lesser apes/great apes divergence, the unique or nonduplicated DNA region underwent amplification and spreading, preferentially marking the p arm of acrocentric chromosomes bearing the rDNA. The mol. anal. of human acrocentric chromosomes revealed some extent of remodeling of the rDNA boundary: near the human NOR, a large 4q35.2 duplication partially resembles that found in MMU; conversely, infrequently represented Yp11.2 sequences totally differed from those of the macaque, and 10p15.3 sequences were lacking. Thus, although evolutionary events modified the sequence organization of the MMU rDNA boundary, its overall sequence feature and the preferential location in vicinity to the NOR have been conserved.
DNA sequences ; Macaca mulatta (boundary of macaque rDNA is constituted by low-copy sequences conserved during evolution)
Settore BIO/13 - Biologia Applicata
nov-2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/22784
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