OBJECTIVE: To evaluate the association between serum complement levels (C3 and C4) and obstetric complications. METHODS: Fifty-seven pregnancies in primary APS (PAPS) patients were compared with 49 pregnancies in patients with UCTD and SS. A group of 175 healthy pregnant women were studied to calculate a normality range for C3 and C4 during pregnancy. Such a range was applied to define hypocomplementaemia in PAPS and UCTD/SS. RESULTS: Both groups of patients (PAPS and UCTD/SS) showed significantly lower levels of C3 and C4 in each trimester as compared with healthy women; conversely, no significant difference was found between PAPS and UCTD/SS. Comparing PAPS pregnancies with and without complications, no difference was found in the prevalence of low C3 or low C4. CONCLUSION: No association was found between hypocomplementaemia and obstetric complications in PAPS. However, both cases of pre-eclampsia were characterized by low C3 throughout pregnancy. There is evidence that the complement system is a contributor to the mechanisms of aPL-mediated damage, but its predictive role on the final pregnancy outcome does not seem to be of major impact.

Primary anti-phospholipid syndrome : any role for serum complement levels in predicting pregnancy complications? / R. Reggia, T. Ziglioli, L. Andreoli, F. Bellisai, A. Iuliano, M. Gerosa, V. Ramoni, C. Tani, A. Brucato, M. Galeazzi, M. Mosca, R. Caporali, P.L. Meroni, A. Tincani. - In: RHEUMATOLOGY. - ISSN 1462-0324. - 51:12(2012 Dec), pp. 2186-2190. [10.1093/rheumatology/kes225]

Primary anti-phospholipid syndrome : any role for serum complement levels in predicting pregnancy complications?

M. Gerosa;A. Brucato;R. Caporali;P.L. Meroni
Penultimo
;
2012

Abstract

OBJECTIVE: To evaluate the association between serum complement levels (C3 and C4) and obstetric complications. METHODS: Fifty-seven pregnancies in primary APS (PAPS) patients were compared with 49 pregnancies in patients with UCTD and SS. A group of 175 healthy pregnant women were studied to calculate a normality range for C3 and C4 during pregnancy. Such a range was applied to define hypocomplementaemia in PAPS and UCTD/SS. RESULTS: Both groups of patients (PAPS and UCTD/SS) showed significantly lower levels of C3 and C4 in each trimester as compared with healthy women; conversely, no significant difference was found between PAPS and UCTD/SS. Comparing PAPS pregnancies with and without complications, no difference was found in the prevalence of low C3 or low C4. CONCLUSION: No association was found between hypocomplementaemia and obstetric complications in PAPS. However, both cases of pre-eclampsia were characterized by low C3 throughout pregnancy. There is evidence that the complement system is a contributor to the mechanisms of aPL-mediated damage, but its predictive role on the final pregnancy outcome does not seem to be of major impact.
Young Adult; Reference Values; Pregnancy Complications; Humans; Retrospective Studies; Complement C3; Complement C4; Pregnancy; Prospective Studies; Adult; Case-Control Studies; Pregnancy Trimesters; Antiphospholipid Syndrome; Prenatal Diagnosis; Female; Pregnancy Outcome
Settore MED/16 - Reumatologia
dic-2012
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/217613
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