Università degli Studi di Milano   Archivio Istituzionale della Ricerca
Please use this identifier to cite or link to this item: http://hdl.handle.net/2434/213683

Title: The immunobiology of apotransferrin in type 1 diabetes
Authors: SELMI, CARLO FRANCESCO
MERONI, PIERLUIGI (Second to last author)
Abstract: The transferrin (Tf) family of iron binding proteins includes important endogenous modulators of the immune function that may modulate autoimmune diseases. To define more clearly the role of apotransferrin (apoTf) in type 1 diabetes we determined the impact of this protein on type 1 diabetes as investigated in islet cells, animal models and patient sera. First, we demonstrated that recombinant apoTf counteracts the cytokine-induced death of murine pancreatic islet cells. Secondly, human apoTf administration favourably influences the course of type 1 diabetes in animal models, resulting in protection against disease development that was associated with reduction of insulitis and reduced levels of proinflammatory cytokines. Finally, we confirmed that patients with newly diagnosed type 1 diabetes manifest significantly lower apoTf serum levels compared to healthy controls and patients with long-lasting disease. In conclusion, our data suggest the apoTf pivotal role in the perpetuation of type 1 diabetes pathology.
MIUR subjects: MED/16 - Reumatologia
Publication date: 2012
Digital Object Identifier (DOI): 10.1111/j.1365-2249.2012.04619.x
Citation: The immunobiology of apotransferrin in type 1 diabetes / K. Mangano, P. Fagone, M. Di Mauro, E. Ascione, V. Maiello, T. Milicic, A. Jotic, N.M. Lalic, T. Saksida, I. Stojanovic, C. Selmi, C. Farina, S. Stosic-Grujicic, P. Meroni, F. Nicoletti. - In: Clinical & experimental immunology. - ISSN 0009-9104. - ISSN 1365-2249. - 169:3(2012), pp. 244-252.
Type: Article (author)

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