Despite eradication programs, bovine tuberculosis is still a sanitary and economic problem in Italy. Genetic effect on immune response to M.bovis plays a central role to determine resistance or susceptibility to disease. The two genes so far identified as involved in immunity to TB are Major Histocompatibility Complex (MHC) and natural resistance associated macrophage protein 1 (NRAMP1). MHC polymorphism modulates antigen presentation and immune paths activation; NRAMP1 determines the ability of macrophages to control M. bovis infection. It has been demonstrated that NRAMP1 even influences the level of MHC class II expression. In this study we have analysed the polymorphisms and sequences of the MHC antigen-binding grove in calves immunised to M.bovis in relation to specific immune response. Moreover bovine NRAMP1 gene has been sequenced and analysed by SSCP technique and microsatellite analysis. Parole chiave: Tubercolosi, Bovino, MHC, NRAMP1.
Identificazione di geni maggiori d’interesse economico (ETL) per la resistenza alle malattie / M. Zanotti, M. Longeri, L. DEL BO - In: Identificazione ed utilizzazione di geni che influenzano la variabilità delle caratteristiche di interesse economico negli animali domestici[s.l] : Arsia - Agenzia Regionale Per Lo Sviluppo E L'innovazione Nel Settore Agricolo Forestale, 2000 Jun. - pp. 99-121 (( convegno Giornata di studio Identificazione ed utilizzazione di geni che influenzano la variabilità delle caratteristiche di interesse economico negli animali domestici tenutosi a Pisa nel 2000.
Identificazione di geni maggiori d’interesse economico (ETL) per la resistenza alle malattie
M. ZanottiPrimo
;M. LongeriSecondo
;
2000
Abstract
Despite eradication programs, bovine tuberculosis is still a sanitary and economic problem in Italy. Genetic effect on immune response to M.bovis plays a central role to determine resistance or susceptibility to disease. The two genes so far identified as involved in immunity to TB are Major Histocompatibility Complex (MHC) and natural resistance associated macrophage protein 1 (NRAMP1). MHC polymorphism modulates antigen presentation and immune paths activation; NRAMP1 determines the ability of macrophages to control M. bovis infection. It has been demonstrated that NRAMP1 even influences the level of MHC class II expression. In this study we have analysed the polymorphisms and sequences of the MHC antigen-binding grove in calves immunised to M.bovis in relation to specific immune response. Moreover bovine NRAMP1 gene has been sequenced and analysed by SSCP technique and microsatellite analysis. Parole chiave: Tubercolosi, Bovino, MHC, NRAMP1.
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