Local delivery of pharmacologic agents or genes at the site of angioplasty is a promising approach to reduce restenosis. However, there are unresolved questions concerning the safety and feasibility of local vascular delivery in clinical practice as well as the efficacy of delivered drug. To this end, the safety, feasibility, and efficacy of local delivery of heparin were evaluated in the Heparin Infusion Prior to Stenting (HIPS) trial.
Heparin infusion prior to stenting (HIPS) trial : final results of a prospective, randomized, controlled trial evaluating the effects of local vascular delivery on intimal hyperplasia / R.L. Wilensky, J.F. Tanguay, S. Ito, A. Bartorelli, J. Moses, D.O. Williams, S.R. Bailey, J. Martin, T.A. Bucher, P. Gallant, A. Greenberg, J.J. Popma, N.J. Weissman, G.S. Mintz, A.V. Kaplan, M.B. Leon. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - 139:6(2000 Jun), pp. 1061-1070. [10.1067/mhj.2000.106614]
Heparin infusion prior to stenting (HIPS) trial : final results of a prospective, randomized, controlled trial evaluating the effects of local vascular delivery on intimal hyperplasia
A. Bartorelli;
2000
Abstract
Local delivery of pharmacologic agents or genes at the site of angioplasty is a promising approach to reduce restenosis. However, there are unresolved questions concerning the safety and feasibility of local vascular delivery in clinical practice as well as the efficacy of delivered drug. To this end, the safety, feasibility, and efficacy of local delivery of heparin were evaluated in the Heparin Infusion Prior to Stenting (HIPS) trial.
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