We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.

IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai / M. Biasin, A. Boasso, L. Piacentini, D. Trabattoni, G. Magri, R. Deshmuks, A. Deshpande, M. Clerici. - In: AIDS. - ISSN 0269-9370. - 17:10(2003), pp. 1563-1566.

IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai

M. Biasin
Primo
;
A. Boasso
Secondo
;
L. Piacentini;D. Trabattoni;M. Clerici
Ultimo
2003

Abstract

We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.
Settore MED/04 - Patologia Generale
2003
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/21079
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 9
social impact