We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.
IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai / M. Biasin, A. Boasso, L. Piacentini, D. Trabattoni, G. Magri, R. Deshmuks, A. Deshpande, M. Clerici. - In: AIDS. - ISSN 0269-9370. - 17:10(2003), pp. 1563-1566.
IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai
M. BiasinPrimo
;A. BoassoSecondo
;L. Piacentini;D. Trabattoni;M. ClericiUltimo
2003
Abstract
We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.Pubblicazioni consigliate
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