Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of 125I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.

Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts / J.L. Lorenzo, M. Allorio, F. Bernini, A. Corsini, R. Fumagalli. - In: FEBS LETTERS. - ISSN 0014-5793. - 218:1(1987 Jun 22), pp. 77-80.

Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts

A. Corsini
Penultimo
;
1987

Abstract

Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of 125I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.
(Human fibroblast); 26-Hydroxycholesterol; LDL; LDL receptor; Oxysterol
Settore BIO/14 - Farmacologia
22-giu-1987
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/209505
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