Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.
Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease / R.W. Mahley, B.P. Nathan, S. Bellosta, R.E. Pitas. - In: CURRENT OPINION IN LIPIDOLOGY. - ISSN 0957-9672. - 6:2(1995 Apr), pp. 86-91.
Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease
S. BellostaPenultimo
;
1995
Abstract
Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.
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