The spectrum of the clinical manifestations of congenital factor X deficiency was studied in 32 Iranian patients. The most frequent symptom was epistaxis, which occurred in 72% of patients, with all degrees of deficiency Other mucosal haemorrhages (e.g. haematuria, gastrointestinal bleeding) were less frequent and occurred mainly in patients with unmeasurable factor X. Menorrhagia occurred in hall: of the women of reproductive age. Soft tissue bleeding occurred in two-thirds of the patients: spontaneous haematomas and haemarthroses led to severe arthropathy in five patients. Bleeding from the umbilical stump was an unexpected finding: in nine patients. This study demonstrated that the bleeding tendency of factor X deficiency is severe and correlates with factor levels.
Congenital factor X deficiency: spectrum of bleeding symptoms in 32 Iranian patients / F. Peyvandi, P.M. Mannucci, M. Lak, M. Abdoullahi, S. Zeinali, R. Sharifian, D. Perry. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 102:2(1998), pp. 626-628.
Congenital factor X deficiency: spectrum of bleeding symptoms in 32 Iranian patients
F. PeyvandiPrimo
;P.M. MannucciSecondo
;
1998
Abstract
The spectrum of the clinical manifestations of congenital factor X deficiency was studied in 32 Iranian patients. The most frequent symptom was epistaxis, which occurred in 72% of patients, with all degrees of deficiency Other mucosal haemorrhages (e.g. haematuria, gastrointestinal bleeding) were less frequent and occurred mainly in patients with unmeasurable factor X. Menorrhagia occurred in hall: of the women of reproductive age. Soft tissue bleeding occurred in two-thirds of the patients: spontaneous haematomas and haemarthroses led to severe arthropathy in five patients. Bleeding from the umbilical stump was an unexpected finding: in nine patients. This study demonstrated that the bleeding tendency of factor X deficiency is severe and correlates with factor levels.Pubblicazioni consigliate
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