LTC4 administered intravenously (0.4–1.6 nmoles/kg) to anaesthetized guineapigs induces constriction of peripheral airway and fall of systemic arterial pressure preceded by a short lasting increase. These effects seem to be related with the appearance in the circulating blood of TXA2 and PGI2-like activity as monitored by tonus changes of RbA and BCA. Pretreatment of the animals with aspirin (0.05 mmoles/kg i.v.) significantly reduces the effects of LTC4 both on pulmonary mechanics and blood pressure. Lungs seem to be a source of arachidonic acid metabolites released by LTC4
Leukotriene-C4 induces generation of PGI2 and TXA2 in guinea-pig in vivo / C. Omini, G.C. Folco, T. Viganò, G. Rossoni, G. Brunelli, F. Berti. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 13:7(1981), pp. 633-640.
Leukotriene-C4 induces generation of PGI2 and TXA2 in guinea-pig in vivo
G. Rossoni;
1981
Abstract
LTC4 administered intravenously (0.4–1.6 nmoles/kg) to anaesthetized guineapigs induces constriction of peripheral airway and fall of systemic arterial pressure preceded by a short lasting increase. These effects seem to be related with the appearance in the circulating blood of TXA2 and PGI2-like activity as monitored by tonus changes of RbA and BCA. Pretreatment of the animals with aspirin (0.05 mmoles/kg i.v.) significantly reduces the effects of LTC4 both on pulmonary mechanics and blood pressure. Lungs seem to be a source of arachidonic acid metabolites released by LTC4
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