PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.
Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities / S. Rusconi, M. Moonis, D.P. Merrill, P.V. Pallai, E.A. Neidhardt, S.K. Singh, K.J. Willis, M.S. Osburne, A.T. Profy, J.C. Jenson, M.S. Hirsch. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 40:1(1996 Jan), pp. 234-236.
Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities
S. RusconiPrimo
;
1996
Abstract
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.
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1996 AAC Naphthalene Sulfonate.pdf
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