Height and breast cancer risk

The relationship between adult height and breast cancer risk was considered, combining data from two case-control studies, one conducted between 1983 and 1991 in northern Italy and the other between 1991 and 1994 in six Italian centres. Cases were 5984 women, below the age of 75 years, with histologically confirmed breast cancer, and controls were 5504 women admitted to hospital for a wide spectrum of acute, non-neoplastic, non-hormone-related diseases. No relationship was observed between height and the risk of breast cancer, with a multivariate odds ratio (OR) of 0.96 (95% confidence intervals (CI) 0.85-1.08) for the tallest women (height > or = 166 cm) compared with the shortest (height < 156 cm). No significant heterogeneity was found across strata of age at diagnosis, education, body mass index, body weight, alcohol intake, age at menarche and menopause, parity, age at first birth, ever use of oral contraceptives and hormone replacement therapy, history of benign breast disease and family history of breast cancer. Thus, this study indicates that adult height is not appreciably related to breast cancer risk in this Italian population.