Objective: To determine the efficacy of superovulation with buserelin acetate, human menopausal gonadotropins (hMG), and human chorionic gonadotropin (hCG) in the treatment of infertility associated with minimal or mild endometriosis. Design: Prospective, randomized, controlled study. Subjects: Forty-nine infertile women with a laparoscopic diagnosis of endometriosis stage I (n = 29) or II (n = 20) according to the revised American Fertility Society classification, randomly assigned to three superovulation cycles (n = 24) or 6 months' expectant management (n = 25). Main Outcome Measures: Cycle fecundity rates and cumulative pregnancy rates (CPR) in the two groups. Results: Nine pregnancies were obtained in the superovulation-treated patients and six in the nontreated ones. The cycle fecundity rates and CPR were 0.15% and 37.4% after three superovulation cycles and 0.045% and 24% after 6 months of expectant management (P < 0.05 and P = not significant, respectively). The women who did not achieve a pregnancy after three cycles of superovulation were followed for a total of 50 months during which no therapy was given. One pregnancy started in this period (cycle fecundity rate = 0.020). One spontaneous abortion occurred in each group. Three treated patients had multiple pregnancies, and four had ovarian hyperstimulation syndrome. Conclusion: Superovulation seems to be associated with a better cycle fecundity rate but not a better CPR than expectant management in infertile women with endometriosis stages I and II. The efficacy and side effects of this therapeutic approach should be evaluated in larger series.

Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis : a controlled randomized study / L. Fedele, S. Bianchi, M. Marchini, L. Villa, D. Brioschi, F. Parazzini. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 58:1(1992 Jul), pp. 28-31. [10.1016/S0015-0282(16)55132-2]

Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis : a controlled randomized study

L. Fedele;S. Bianchi;F. Parazzini
1992

Abstract

Objective: To determine the efficacy of superovulation with buserelin acetate, human menopausal gonadotropins (hMG), and human chorionic gonadotropin (hCG) in the treatment of infertility associated with minimal or mild endometriosis. Design: Prospective, randomized, controlled study. Subjects: Forty-nine infertile women with a laparoscopic diagnosis of endometriosis stage I (n = 29) or II (n = 20) according to the revised American Fertility Society classification, randomly assigned to three superovulation cycles (n = 24) or 6 months' expectant management (n = 25). Main Outcome Measures: Cycle fecundity rates and cumulative pregnancy rates (CPR) in the two groups. Results: Nine pregnancies were obtained in the superovulation-treated patients and six in the nontreated ones. The cycle fecundity rates and CPR were 0.15% and 37.4% after three superovulation cycles and 0.045% and 24% after 6 months of expectant management (P < 0.05 and P = not significant, respectively). The women who did not achieve a pregnancy after three cycles of superovulation were followed for a total of 50 months during which no therapy was given. One pregnancy started in this period (cycle fecundity rate = 0.020). One spontaneous abortion occurred in each group. Three treated patients had multiple pregnancies, and four had ovarian hyperstimulation syndrome. Conclusion: Superovulation seems to be associated with a better cycle fecundity rate but not a better CPR than expectant management in infertile women with endometriosis stages I and II. The efficacy and side effects of this therapeutic approach should be evaluated in larger series.
endometriosis; fertility; human gonadotropins; Superovulation
Settore MED/40 - Ginecologia e Ostetricia
lug-1992
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/206312
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