Università degli Studi di Milano   Archivio Istituzionale della Ricerca
Please use this identifier to cite or link to this item: http://hdl.handle.net/2434/206235

Title: Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali : l'esempio del "Seveso molecular epidemiology project"
Authors: PESATORI, ANGELA CECILIA (Second author)
BACCARELLI, ANDREA (First author)
BONZINI, MATTEO
MARINELLI, BARBARA
BERTAZZI, PIETRO ALBERTO (Second to last author)
Abstract: In 1997, IARC classified 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as carcinogenic to humans, based on sufficient evidence from animal data and limited evidence from human data. A key role in the IARC classification was played by the well-defined mechanism of TCDD action involving the activation of the Arylhydrocarbon Receptor (AhR). Experimental animal and in-vitro studies indicate that AhR levels decrease following TCDD binding. Nearly 20 years after the Seveso accident, we found a decrease in AhR mRNA levels in TCDD-exposed subjects. AhR transcript levels were correlated with plasma TCDD concentrations. Our results may reflect a down-regulation of AhR, similar to that observed in most receptorial systems. We demonstrated, for the first time in humans, that TCDD-related regulation of the AhR pathway, previously observed in experimental studies, may also occur in exposed subjects. Our data are important for extrapolating AhR-mediated effects from experimental models to humans.
Keywords: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ; Aryl-hydrocarbon Receptor ; Environmental exposure
MIUR subjects: MED/44 - Medicina del Lavoro
Publication date: 2004
Citation: Metodologie molecolari e genetiche nello studio degli effetti di agenti occupazionali ed ambientali : l'esempio del "Seveso molecular epidemiology project" / A. Baccarelli, A.C. Pesatori, D. Consonni, D. Patterson Jr., M. Bonzini, B. Marinelli, J.A. Grassman, P.A. Bertazzi, M.T. Landi. - In: Giornale italiano di medicina del lavoro e di ergonomia. - ISSN 1592-7830. - 26:suppl al n. 4(2004), pp. 22-23. ((Intervento presentato al 67. convegno Congresso nazionale SIMLII : Monitoraggio biologico e ambienti confinati non industriali : aggiornamenti e prospettive tenutosi a Sorrento nel 2004.
Type: Article (author)

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