Aim: According to Italian Guidelines, statin therapy is recommended for children aged 10 or more who, despite 6-12 months of dietary treatment, present elevated LDL-C levels (LDL-C>190 mg/dl without other risk factors, LDL-C>160 with other risk factors). The aim of this study is to evaluate the effect of one month pravastatin therapy on lipidic profile of a population of chldren with familial hypercholesterolemia followed in our Lipid Clinic. Methods: We investigated a population of 15 children with familial hypercholesterolemia (14 genetical diagnosis, 1 clinical diagnosis; 9M, 6F, 14.6y), already put on a fat restricted diet for 12 months. Blood samples for measurements of lipid profile were collected at baseline and after one month of pravastatin treatment 20 mg/die. The lipid profile at the first determination was (mean values mg/dl): TC 292.3 (sd 39.6), LDL-C 219.7 (sd 46.9), HDL 50.6 (sd 9.9), Tryglicerides 92.8 (sd 46.1). Statistics: paired t-Student test. Results: After one month pravastatin therapy TC, LDL-C and tryglicerides were significantly reduced. Mean(sd) (mean values mg/dl) of TC, LDL-C, HDL-C and tryglicerides before and after treatment were, respectively, 292.3 (39.6) vs 226.8 (31), p < 0.0001; 219.7 (46.9) vs 168.7 (29.3), p< 0.0001; 50.6 (9.9) vs 50.5 (9.3), p = 0.975; 92.8 (46.1) vs 71.9 (28.5), p< 0.05. Conclusions: These preliminary findings suggest that pravastatin therapy, added to dietary and behavioural treatment, can significantly reduce CT, LDL-C and tryglicerides levels in a population of children with familial hypercholesterolemia, with no effect on HDL-C. This positive effect is worth further investigations.

STATIN THERAPY IN A POPULATION OF ITALIAN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA: EFFECT ON BLOOD LIPID PROFILE / E. Riva, M.E. Capra, A. Domi, E. Salvatici, M. Giovannini, C.A. Pederiva. ((Intervento presentato al 80. convegno European Atherosclerosis Society Congress tenutosi a Milano nel 2012.

STATIN THERAPY IN A POPULATION OF ITALIAN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA: EFFECT ON BLOOD LIPID PROFILE

E. Riva
Primo
;
M.E. Capra
Secondo
;
A. Domi;E. Salvatici;M. Giovannini
Penultimo
;
C.A. Pederiva
Ultimo
2012

Abstract

Aim: According to Italian Guidelines, statin therapy is recommended for children aged 10 or more who, despite 6-12 months of dietary treatment, present elevated LDL-C levels (LDL-C>190 mg/dl without other risk factors, LDL-C>160 with other risk factors). The aim of this study is to evaluate the effect of one month pravastatin therapy on lipidic profile of a population of chldren with familial hypercholesterolemia followed in our Lipid Clinic. Methods: We investigated a population of 15 children with familial hypercholesterolemia (14 genetical diagnosis, 1 clinical diagnosis; 9M, 6F, 14.6y), already put on a fat restricted diet for 12 months. Blood samples for measurements of lipid profile were collected at baseline and after one month of pravastatin treatment 20 mg/die. The lipid profile at the first determination was (mean values mg/dl): TC 292.3 (sd 39.6), LDL-C 219.7 (sd 46.9), HDL 50.6 (sd 9.9), Tryglicerides 92.8 (sd 46.1). Statistics: paired t-Student test. Results: After one month pravastatin therapy TC, LDL-C and tryglicerides were significantly reduced. Mean(sd) (mean values mg/dl) of TC, LDL-C, HDL-C and tryglicerides before and after treatment were, respectively, 292.3 (39.6) vs 226.8 (31), p < 0.0001; 219.7 (46.9) vs 168.7 (29.3), p< 0.0001; 50.6 (9.9) vs 50.5 (9.3), p = 0.975; 92.8 (46.1) vs 71.9 (28.5), p< 0.05. Conclusions: These preliminary findings suggest that pravastatin therapy, added to dietary and behavioural treatment, can significantly reduce CT, LDL-C and tryglicerides levels in a population of children with familial hypercholesterolemia, with no effect on HDL-C. This positive effect is worth further investigations.
mag-2012
Settore MED/38 - Pediatria Generale e Specialistica
European Atherosclerosis Society
http://www.kenes.com/eas2012/abstracts/pdf/402.pdf
STATIN THERAPY IN A POPULATION OF ITALIAN CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA: EFFECT ON BLOOD LIPID PROFILE / E. Riva, M.E. Capra, A. Domi, E. Salvatici, M. Giovannini, C.A. Pederiva. ((Intervento presentato al 80. convegno European Atherosclerosis Society Congress tenutosi a Milano nel 2012.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/204363
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