Levodopa (L-DOPA)-induced dyskinesias represent the main side effect of the therapeutic strategy clinically used in Parkinson's disease (PD) treatment. The first beneficial "honeymoon" phase of L-DOPA therapy is followed by a phase of deterioration in which L-DOPA administration causes motor fluctuations in the drug efficacy ("on-off" state) and dyskinesias. Alterations of the composition and function of N-methyl-D-aspartate (NMDA) receptor represent one of the main causes for the striatal synaptic changes described in experimental model of dyskinesias. In the present study, the modulation of the composition of synaptic NMDA receptor by using a cell-permeable peptide targeting NR2A subunit during the development of dyskinesias led to a reduction of the percentage of parkinsonian rats developing dyskinetic movements.

Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias / F. Gardoni, C. Sgobio, V. Pendolino, P. Calabresi, M. Di Luca, B. Picconi. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 33:9(2012 Aug), pp. 2138-2144. [10.1016/j.neurobiolaging.2011.06.019]

Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias

F. Gardoni
Primo
;
M. Di Luca
Penultimo
;
2012

Abstract

Levodopa (L-DOPA)-induced dyskinesias represent the main side effect of the therapeutic strategy clinically used in Parkinson's disease (PD) treatment. The first beneficial "honeymoon" phase of L-DOPA therapy is followed by a phase of deterioration in which L-DOPA administration causes motor fluctuations in the drug efficacy ("on-off" state) and dyskinesias. Alterations of the composition and function of N-methyl-D-aspartate (NMDA) receptor represent one of the main causes for the striatal synaptic changes described in experimental model of dyskinesias. In the present study, the modulation of the composition of synaptic NMDA receptor by using a cell-permeable peptide targeting NR2A subunit during the development of dyskinesias led to a reduction of the percentage of parkinsonian rats developing dyskinetic movements.
Cell-permeable peptides; Dopamine; Dyskinesias; NMDA receptor; Parkinson's disease; Striatum; Synaptic plasticity
Settore BIO/14 - Farmacologia
ago-2012
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/203119
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 51
social impact