Objective: We propose here a new approach to compute IMT progression, which performs much better than progression variables used so far. Methods: The fastest IMT progression (Fastest-IMTprogr) is defined as the fastest local IMT change occurring in any spot of the whole carotid tree over a definite time period, regardless of its location. The IMPROVE study dataset (3703 subjects) was analyzed to investigate the performances of the Fastest-IMTprogr in terms of association with vascular risk factors (VRFs), association with vascular events, and signal-to-noise ratio (average annual progression over measurement error), as compared to conventional progression variables. Results: By Cox analysis, the Fastest-IMTprogr was the only progression variable significantly associated with combined vascular events (age and gender adjusted hazard ratio (95%CI): 2.02 (1.33-3.06), p=0.0009). Moreover, its association with VRFs was stronger than any other progression variables: multivariate R2=0.24 vs. 0.11 (using the progression of mean common carotid). Finally, the signal-to-noise ratio of the Fastest-IMTprogr was 4.8 times greater than that of the second best performing variable ( IMTmean-max progression). Conclusions: The Fastest-IMTprogr performs much better than all the other IMT-progression variables considered, and, as such, it may represent the best target to investigate the effects of anti-atherosclerosis therapies.

Fastest IMT progression: a novel marker to analyze the evolution of carotid intima-media thickness / F. Veglia, D. Baldassarre, M. Amato, A. Ravani, D. Sansaro, C.C. Tedesco, A. Discacciati, B. Frigerio, E. Tremoli. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 12:1(2011 Jun), pp. 175-175. ((Intervento presentato al 79. convegno European Atherosclerosis society Congress tenutosi a Gothenburg nel 2011 [10.1016/S1567-5688(11)70837-6].

Fastest IMT progression: a novel marker to analyze the evolution of carotid intima-media thickness

D. Baldassarre
Secondo
;
B. Frigerio
Penultimo
;
E. Tremoli
Ultimo
2011

Abstract

Objective: We propose here a new approach to compute IMT progression, which performs much better than progression variables used so far. Methods: The fastest IMT progression (Fastest-IMTprogr) is defined as the fastest local IMT change occurring in any spot of the whole carotid tree over a definite time period, regardless of its location. The IMPROVE study dataset (3703 subjects) was analyzed to investigate the performances of the Fastest-IMTprogr in terms of association with vascular risk factors (VRFs), association with vascular events, and signal-to-noise ratio (average annual progression over measurement error), as compared to conventional progression variables. Results: By Cox analysis, the Fastest-IMTprogr was the only progression variable significantly associated with combined vascular events (age and gender adjusted hazard ratio (95%CI): 2.02 (1.33-3.06), p=0.0009). Moreover, its association with VRFs was stronger than any other progression variables: multivariate R2=0.24 vs. 0.11 (using the progression of mean common carotid). Finally, the signal-to-noise ratio of the Fastest-IMTprogr was 4.8 times greater than that of the second best performing variable ( IMTmean-max progression). Conclusions: The Fastest-IMTprogr performs much better than all the other IMT-progression variables considered, and, as such, it may represent the best target to investigate the effects of anti-atherosclerosis therapies.
Settore BIO/14 - Farmacologia
giu-2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/202806
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