T-cell activation is dependent on signals delivered through the antigen-specific T-cell receptor and accessory receptors on T-cells. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands regulates the balance between T-cell activation, tolerance, and immunopathology. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals and exert a vital and diverse range of immunoregulatory roles in T-cell activation, tolerance, and immune-mediated tissue damage. In this review, we revisit current understanding of the immunoregulatory functions of PD-1 and its ligands and their involvement in immune-mediated diseases.

The PD-1/PD-L1 pathway in human pathology / M. Saresella, V. Rainone, N.M. Al-Daghri, M.S. Clerici, D.L. Trabattoni. - In: CURRENT MOLECULAR MEDICINE. - ISSN 1566-5240. - 12:3(2012 Mar), pp. 259-267.

The PD-1/PD-L1 pathway in human pathology

V. Rainone
Secondo
;
M.S. Clerici
Penultimo
;
D.L. Trabattoni
Ultimo
2012

Abstract

T-cell activation is dependent on signals delivered through the antigen-specific T-cell receptor and accessory receptors on T-cells. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands regulates the balance between T-cell activation, tolerance, and immunopathology. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals and exert a vital and diverse range of immunoregulatory roles in T-cell activation, tolerance, and immune-mediated tissue damage. In this review, we revisit current understanding of the immunoregulatory functions of PD-1 and its ligands and their involvement in immune-mediated diseases.
Settore MED/04 - Patologia Generale
mar-2012
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/202506
Citazioni
  • ???jsp.display-item.citation.pmc??? 24
  • Scopus 65
  • ???jsp.display-item.citation.isi??? 54
social impact