The microbial oxidation of prochiral 2-methyl-1,3-propandiol into (R)-3-hydroxy-2-methyl propionic acid with Acetobacter pasteurianus DSM 8937 is reported. The biotransformation was optimised furnishing (R)-3-hydroxy-2-methyl propionic acid with 97% enantiomeric excess and 100% molar conversion of 5 g/L within 2 h. A simple fed-batch procedure allowed for the obtainment of 25 g/L of the enantiomerically enriched acid. (R)-3-Hydroxy-2-methyl propionic acid is an important building block for the synthesis of Captopril, a widely used antihypertensive drug.
Enantioselective oxidation of prochiral 2-methyl-1,3-propandiol by Acetobacter pasteurianus / F.E. Molinari, R. Gandolfi, R. Villa, E. Urbanb, A. Kienerb. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 14:14(2003), pp. 2041-2043. [10.1016/S0957-4166(03)00407-5]
Enantioselective oxidation of prochiral 2-methyl-1,3-propandiol by Acetobacter pasteurianus
F.E. MolinariPrimo
;R. GandolfiSecondo
;
2003
Abstract
The microbial oxidation of prochiral 2-methyl-1,3-propandiol into (R)-3-hydroxy-2-methyl propionic acid with Acetobacter pasteurianus DSM 8937 is reported. The biotransformation was optimised furnishing (R)-3-hydroxy-2-methyl propionic acid with 97% enantiomeric excess and 100% molar conversion of 5 g/L within 2 h. A simple fed-batch procedure allowed for the obtainment of 25 g/L of the enantiomerically enriched acid. (R)-3-Hydroxy-2-methyl propionic acid is an important building block for the synthesis of Captopril, a widely used antihypertensive drug.
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