Monoterapia e politerapia nelle epilessie farmacoresistenti

Monotherapy is certainly the best choice for the treatment of all types of epilepsy. In severe epilepsies, when one-drug treatments do not obtain seizure control, a second drug is generally used in order to reach a best clinical outcome, but the real advantage of polytherapy versus monotherapy is still not known in these cases. A retrospective survey was carried out on 66 adult patients with different types of epilepsy who had taken two-drug therapy after failure of the initial monotherapy. With polytherapy, only 16.5% of cases showed a reduction in seizure frequency of 75%, 67% showed no modification and in another 16.5% an increase in seizure frequency of 100% was observed. Polytherapy seems to be not more effective of monotherapy in severe epilepsies in order to obtain a best clinical outcome.