We investigated the prevalence of anti-HCV in 160 consecutive patients with primary biliary cirrhosis. By ELISA, 19 (12%) were positive, as compared to a 68% prevalence in 135 patients with chronic non-A, non-B hepatitis. Serum IgG levels were significantly higher in the anti-HCV positive group. By RIBA, seropositivity was confirmed for 4 patients, whereas 7 were indeterminate. A slight, non-significant reduction of life expectancy was found in anti-HCV positive patients. Until reliable and independent confirmatory tests become available, definitive conclusions on the importance of anti-HCV positivity in primary biliary cirrhosis are improper.
Antibodies to hepatitis C virus in primary biliary cirrhosis / E. Bertolini, F. Marelli, P. Zermiani, P. M. Battezzati, M. Zuin, G. A. Moroni, M. Podda. - In: ARCHIVES OF VIROLOGY. SUPPLEMENTUM. - ISSN 0939-1983. - 4(1992), pp. 205-209.
Antibodies to hepatitis C virus in primary biliary cirrhosis
P. Zermiani;P.M. Battezzati;M. Zuin;M. PoddaUltimo
1992
Abstract
We investigated the prevalence of anti-HCV in 160 consecutive patients with primary biliary cirrhosis. By ELISA, 19 (12%) were positive, as compared to a 68% prevalence in 135 patients with chronic non-A, non-B hepatitis. Serum IgG levels were significantly higher in the anti-HCV positive group. By RIBA, seropositivity was confirmed for 4 patients, whereas 7 were indeterminate. A slight, non-significant reduction of life expectancy was found in anti-HCV positive patients. Until reliable and independent confirmatory tests become available, definitive conclusions on the importance of anti-HCV positivity in primary biliary cirrhosis are improper.
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