Mechanisms of thrombosis induced by antiphospholipid (aPL) antibodies include up-regulation of tissue factor (TF) expression on endothelial cells (ECs). Statins have been shown to reduce levels of TF induced by tumor necrosis factor (TNF-alpha) and lipopolysaccharide (LPS) on ECs. In a recent study, fluvastatin inhibited thrombogenic and proinflammatory properties of aPL antibodies in in vivo models. The aim of this study was to determine whether fluvastatin has an effect on aPL-induced expression of TF on ECs.
Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells / D. E. Ferrara, R. Swerlick, K. Casper, P. L. Meroni, M. E. Vega-Ostertag, E. N. Harris, S. S. Pierangeli. - In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. - ISSN 1538-7933. - 2:9(2004 Sep), pp. 1558-1563. [10.1111/j.1538-7836.2004.00896.x]
Fluvastatin inhibits up-regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells
P.L. Meroni;
2004
Abstract
Mechanisms of thrombosis induced by antiphospholipid (aPL) antibodies include up-regulation of tissue factor (TF) expression on endothelial cells (ECs). Statins have been shown to reduce levels of TF induced by tumor necrosis factor (TNF-alpha) and lipopolysaccharide (LPS) on ECs. In a recent study, fluvastatin inhibited thrombogenic and proinflammatory properties of aPL antibodies in in vivo models. The aim of this study was to determine whether fluvastatin has an effect on aPL-induced expression of TF on ECs.
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