Title compds. (I; R = Cl, Br, CF3; n = 0-3; when R = Cl and n = 1-3, then the H atoms at the 1 and 9a positions of the quinolizidinyl ring are trans), were prepd. Thus, 4,7-dichloroquinoline and 1-quinolizidinylamine were refluxed with PhOH for 4 h at 180 to give a separable mixt. of cis, trans-4-(1-quinolizidinylamino)-7-chloroquinoline. The latter showed 6-8 times the antimalarial activity of chloroquine against W2 P. falciparum.
4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity / A. Sparatore, D. Taramelli, N. Basilico, S. Parapini, F. Sparatore, V. Boido, C. Canu Boido.
4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity
A. Sparatore;D. Taramelli;N. Basilico;S. Parapini;
2005
Abstract
Title compds. (I; R = Cl, Br, CF3; n = 0-3; when R = Cl and n = 1-3, then the H atoms at the 1 and 9a positions of the quinolizidinyl ring are trans), were prepd. Thus, 4,7-dichloroquinoline and 1-quinolizidinylamine were refluxed with PhOH for 4 h at 180 to give a separable mixt. of cis, trans-4-(1-quinolizidinylamino)-7-chloroquinoline. The latter showed 6-8 times the antimalarial activity of chloroquine against W2 P. falciparum.
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