Administration of dihydroxydibutylether (DHBE, Dis-Cinil) to rats with ethynylestradiol(EE)-induced cholestasis provoked an increase in bile flow and output of bile acids and phospholipids. Since EE-induced cholestasis is related to the condition observed in humans, a clinical trial of DHBE in cholestatic syndromes seems worthwhile.
Effect of dihydroxydibutylether (DHBE) on bile flow and composition in rats with ethynylestradiol-induced cholestasis / M. Podda, M. Zuin, M. L. Dioguardi, S. Festorazzi, C. Di Padova. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 30:12(1980), pp. 2126-2128.
Effect of dihydroxydibutylether (DHBE) on bile flow and composition in rats with ethynylestradiol-induced cholestasis
M. PoddaPrimo
;M. ZuinSecondo
;
1980
Abstract
Administration of dihydroxydibutylether (DHBE, Dis-Cinil) to rats with ethynylestradiol(EE)-induced cholestasis provoked an increase in bile flow and output of bile acids and phospholipids. Since EE-induced cholestasis is related to the condition observed in humans, a clinical trial of DHBE in cholestatic syndromes seems worthwhile.
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