There is an urgent need for modalities that can localize and prolong the administration of the antitumor agents, particularly antiangiogenic, to achieve long-term tumor inhibition. However, one of the major obstacles is designing a device in which the biological activity of sensitive endogenous inhibitors is retained. We have designed a biodegradable polymeric device, which provides a unique and practical means of localizing and continuously delivering hemopexin (PEX) or platelet factor 4 fragment (PF-4/CTF) at the tumor site while maintaining their biological activity. The potential and efficacy of this system is shown in vitro and in vivo in a human glioma mouse model.

Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth / O. Benny, M. Duvshani-Eshet, T. Cargioli, L. Bello, A. Bikfalvi, R. S. Carroll, M. Machluf. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - 11:2 Pt 1(2005 Jan 15), pp. 768-76-776.

Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth

L. Bello;
2005

Abstract

There is an urgent need for modalities that can localize and prolong the administration of the antitumor agents, particularly antiangiogenic, to achieve long-term tumor inhibition. However, one of the major obstacles is designing a device in which the biological activity of sensitive endogenous inhibitors is retained. We have designed a biodegradable polymeric device, which provides a unique and practical means of localizing and continuously delivering hemopexin (PEX) or platelet factor 4 fragment (PF-4/CTF) at the tumor site while maintaining their biological activity. The potential and efficacy of this system is shown in vitro and in vivo in a human glioma mouse model.
Drug Delivery Systems; Animals; Glioblastoma; Coagulants; Humans; Lactic Acid; Mice, Nude; Mice; Biocompatible Materials; Mice, Inbred BALB C; Endothelial Cells; Microspheres; Hemopexin; Brain Neoplasms; Peptide Fragments; Cattle; Polyglycolic Acid; Platelet Factor 4; Umbilical Veins; Polymers; Male; Immunoenzyme Techniques
Settore MED/27 - Neurochirurgia
15-gen-2005
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/199600
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