This baseline-vs-treatment study of 20 patients with relapsing-remitting MS investigated whether glatiramer acetate (GA) has a graduated effect on MS inflammatory activity, which was measured using monthly, standard, and triple dose gadolinium (Gd)-enhanced MRI. GA significantly reduced the mean numbers of enhancing lesions/patient/month on both standard dose and triple dose scans, without interactions with the Gd dose. GA is effective in reducing MS activity, independent of the severity of the MRI-detectable inflammatory process.

Effect of glatiramer acetate on MS lesions enhancing at different gadolinium doses / M. Rovaris, M. Codella, L. Moiola, A. Ghezzi, M. Zaffaroni, G. Mancardi, E. Capello, F. Sardanelli, G. Comi, M. Filippi. - In: NEUROLOGY. - ISSN 0028-3878. - 59:9(2002 Nov 12), pp. 1429-32-1432.

Effect of glatiramer acetate on MS lesions enhancing at different gadolinium doses

F. Sardanelli;
2002

Abstract

This baseline-vs-treatment study of 20 patients with relapsing-remitting MS investigated whether glatiramer acetate (GA) has a graduated effect on MS inflammatory activity, which was measured using monthly, standard, and triple dose gadolinium (Gd)-enhanced MRI. GA significantly reduced the mean numbers of enhancing lesions/patient/month on both standard dose and triple dose scans, without interactions with the Gd dose. GA is effective in reducing MS activity, independent of the severity of the MRI-detectable inflammatory process.
Magnetic Resonance Imaging; Humans; Gadolinium; Adult; Treatment Outcome; Peptides; Middle Aged; Adolescent; Multiple Sclerosis, Relapsing-Remitting; Immunosuppressive Agents
Settore MED/36 - Diagnostica per Immagini e Radioterapia
12-nov-2002
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/198532
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