In order to compare the effects on gallstone dissolution of three different doses of UDCA (4, 8 and 12 mg/kg/day), a controlled trial was carried out with seventy-one patients. The dissolution rate was higher in the group treated with the highest dose. Stone size was the major factor affecting the outcome of treatment, with a significantly higher success rate in patients with gallstones less than 10 mm than with stones greater than 10 mm.
Gallstone dissolution after 6 months of ursodeoxycholic acid (UDCA): effectiveness of different doses / M. Podda, M. Zuin, N. Carulli, M. Ponz de Leon, M. L. Dioguardi. - In: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. - ISSN 0300-0605. - 10:1(1982), pp. 59-63. [10.1177/030006058201000112]
Gallstone dissolution after 6 months of ursodeoxycholic acid (UDCA): effectiveness of different doses
M. PoddaPrimo
;M. ZuinSecondo
;M. L. Dioguardi
1982
Abstract
In order to compare the effects on gallstone dissolution of three different doses of UDCA (4, 8 and 12 mg/kg/day), a controlled trial was carried out with seventy-one patients. The dissolution rate was higher in the group treated with the highest dose. Stone size was the major factor affecting the outcome of treatment, with a significantly higher success rate in patients with gallstones less than 10 mm than with stones greater than 10 mm.
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