In February, 1982 a 45-year-old woman was admitted to the hospital for leukopenia and hemorrhagic diathesis. The bone marrow biopsy was positive for acute myeloid leukemia (AML). In a few days the patient developed leukocytosis (95% promyelocytic blasts) and disseminated intravascular coagulation (D.I.C.). She complained of severe headache and photophobia, and moderate nucal stiffness was present as the only neurological alteration. Examination of the CSF revealed blasts, and a cerebral computerized axial tomography (C.A.T.) showed a localization in the right temporal lobe. Complete marrow and central nervous system (CNS) remission were obtained by a single course of daunorubicin I.V. CNS remission was maintained even after a marrow relapse which occurred about two years later.
Cerebral parenchymal involvement in acute promyelocytic leukemia. A case report / E. M. Pogliani, C. Fowst, A. Marozzi, M. Salvatore, E. E. Polli. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 73:1(1988), pp. 71-73.
Cerebral parenchymal involvement in acute promyelocytic leukemia. A case report
A. Marozzi;
1988
Abstract
In February, 1982 a 45-year-old woman was admitted to the hospital for leukopenia and hemorrhagic diathesis. The bone marrow biopsy was positive for acute myeloid leukemia (AML). In a few days the patient developed leukocytosis (95% promyelocytic blasts) and disseminated intravascular coagulation (D.I.C.). She complained of severe headache and photophobia, and moderate nucal stiffness was present as the only neurological alteration. Examination of the CSF revealed blasts, and a cerebral computerized axial tomography (C.A.T.) showed a localization in the right temporal lobe. Complete marrow and central nervous system (CNS) remission were obtained by a single course of daunorubicin I.V. CNS remission was maintained even after a marrow relapse which occurred about two years later.
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