A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.

The tripartite motif family identifies cell compartments / A. Reymond, G. Meroni, A. Fantozzi, G. Merla, S. Cairo, L. Luzi, D. Riganelli, E. Zanaria, S. Messali, S. Cainarca, A. Guffanti, S. Minucci, P. G. Pelicci, A. Ballabio. - In: EMBO JOURNAL. - ISSN 0261-4189. - 20:9(2001 May 01), pp. 2140-51-2151.

The tripartite motif family identifies cell compartments

S. Minucci;P. G. Pelicci;
2001

Abstract

A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
Animals; Blotting, Northern; Carrier Proteins; Multigene Family; Humans; Two-Hybrid System Techniques; Subcellular Fractions; Organ Specificity; Mice; Protein Binding; Chromosome Mapping; Nerve Tissue Proteins; Cloning, Molecular; Mutagenesis, Site-Directed; In Situ Hybridization; Amino Acid Motifs; Cell Compartmentation; Molecular Sequence Data; Databases, Factual; Proteins; Sequence Homology, Amino Acid; Protein Structure, Tertiary; Embryo, Mammalian; Cell Line
Settore MED/04 - Patologia Generale
1-mag-2001
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/195016
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