The ETV6 gene undergoes rearrangements with tyrosine kinases in hematologic malignancies and solid tumors. ETV6/ABL1 chimeric proteins have been detected both in lymphoid and myeloid disorders. Our objective was to study two new cases of ETV6/ABL1-positive acute myeloid leukemia (AML) and to focus on bone marrow morphology and on molecular cytogenetics of eosinophilic cells.
Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia / R. La Starza, M. Trubia, N. Testoni, E. Ottaviani, E. Belloni, B. Crescenzi, M. Martelli, G. Flandrin, P. G. Pelicci, C. Mecucci. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 87:8(2002 Aug), pp. 789-94-794.
Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia
P. G. PelicciPenultimo
;
2002
Abstract
The ETV6 gene undergoes rearrangements with tyrosine kinases in hematologic malignancies and solid tumors. ETV6/ABL1 chimeric proteins have been detected both in lymphoid and myeloid disorders. Our objective was to study two new cases of ETV6/ABL1-positive acute myeloid leukemia (AML) and to focus on bone marrow morphology and on molecular cytogenetics of eosinophilic cells.
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