An overview is given of the design of drugs which interfere with the folding mechanism of the target protein, destabilizing it and making it prone to proteolisis. It is shown that these drugs are efficient, specific, and do not suffer from the upraise of resistance.
Resistance proof, folding-inhibitor drugs / R. A. Broglia, G. Tiana , R. Berera. - In: THE JOURNAL OF CHEMICAL PHYSICS. - ISSN 0021-9606. - 118:10(2003), pp. 4754-4758.
Resistance proof, folding-inhibitor drugs
G. TianaSecondo
;
2003
Abstract
An overview is given of the design of drugs which interfere with the folding mechanism of the target protein, destabilizing it and making it prone to proteolisis. It is shown that these drugs are efficient, specific, and do not suffer from the upraise of resistance.File in questo prodotto:
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