Hierarchy of Events in the folding of model proteins

The protein folding problem, i.e. prediction of the detailed three-dimensional structure of a known real protein sequence is discussed. All the information about the structure is present in the amino acid sequence. Proteins under normal condition will fold to their native state. Good folder sequence are charcterized by large gap between the energy sequence. The local elementary structures are formed at the very early stages of the composition process. The designed sequence displays same folding mechanism.